Pontypool had an interesting concept, to say the least. A local radio station in the middle of what looks to be a zombie outbreak (or something akin to that). And in all fairness, it had some good moments. A good build up during the bit when they realise that there's something serious going and the final scene with Ken Loney is touching.
That said, I could not help but think they did not fully reach the potential this concept has to offer. With a few on location shots (think of reporters like Trevor Hannah in the Dawn of the Dead remake), good voice actors who earned their chops in animation, good use of facial expressions,...
All in all, I liked it (and I respect what the crew did with this budget), but I can also not help but wonder what someone like David Fincher could have done with this.